DoctorJack Auty

My research investigates inflammation and tissue damage across environmental, biological, and clinical contexts, linking disease and injury to immune signalling, tissue damage, and disease. I work across systems, from wildlife studies on remote islands to human epidemiological research, tissue pathology, blood-based biomarkers, and cell-based models.

A key strand of my work examines the health impacts of microplastic exposure in wildlife and humans. This is integrated with research on inflammatory mechanisms underlying neurological injury, dementia, and Alzheimer’s disease, with a particular focus on how inflammation contributes to organ damage.

Central to my research is understanding how inflammatory signalling shifts from adaptive to maladaptive states. I focus on cytokine pathways, especially IL-1α and IL-1β, identifying the triggers and modulators of these signals and linking them to tissue pathology and measurable circulating biomarkers. This integrated approach aims to generate mechanistic insight that informs both disease prevention and therapeutic development.